一项针对医生指导的基因组学模型的试点回顾性研究,用于精确的生活方式医学
Michael Mallin1, Jane Hall2, Maria Herlihy1
1Wild Health, Inc., Lexington, KY, United States.
Frontiers in medicine
|November 9, 2023
概括
在一项试点研究中,由医生领导的基于基因组学的生活方式指导改善了关键的健康生物标志物. 许多患者在没有药物治疗的情况下看到血红蛋白A1c,LDL-P和C反应蛋白的正常水平.
科学领域:
- 精准医学是一门精准的医学.
- 基因组学就是基因组学.
- 主要的护理是初级保健.
背景情况:
- 精确的生活方式医学将遗传倾向与饮食和运动等干预措施相结合.
- 有限的研究存在于医生指导的基因组学基础的慢性疾病管理计划.
- 商业基因组测试越来越多.
研究的目的:
- 评估野生健康计划对慢性疾病的生物标志物的影响.
- 评估提供基于基因组学的生活方式和医疗干预的医生和健康教练服务的影响.
主要方法:
- 一项试点,观察性队列研究,涉及871名患者.
- 患者接受了基因组测试,生物标志物测试和医疗后咨询健康指导.
- 对生物标志物变化的回顾性数据分析.
主要成果:
- 大多数患者在临床相关的,范围之外的生物标志物中观察到显著改善.
- 血红蛋白A1c (HbA1c) 的正常化率为47.5%,低密度脂蛋白颗粒数 (LDL-P) 为33.3%,C反应蛋白 (CRP) 为33.2%.
- 这些改善主要是通过生活方式干预来实现,而不是通过处方药来实现.
结论:
- 医生主导的基于基因组的生活方式指导在改善慢性疾病生物标志物方面显示出前景.
- 由遗传洞察力指导的生活方式干预,可以有效地优化健康结果.
- 需要进一步的研究,包括随机对照试验,以确认有效性和探索特定干预措施.
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