亚斯科伯酸盐可以保护人类器官免受由无细胞血红蛋白引起的损伤
Julie Bejoy1, Justin M Farry1,2, Eddie S Qian1
1Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Disease models & mechanisms
|November 9, 2023
概括
在败血症中,无细胞血红蛋白 (CFH) 会导致脏损伤. 亚斯科伯酸盐 (维生素C) 显著保护人类脏器官免受CFH诱导的损伤,这表明可能治疗败血症相关的急性脏损伤.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 细胞生物学 细胞生物学
- 临界护理医学 临界护理医学
背景情况:
- 败血症相关的急性损伤 (AKI) 是重症患者的严重并发症,与高死亡率有关.
- 在严重败血症期间释放的无细胞血红蛋白 (CFH) 独立地与死亡率相关,并导致管状细胞损伤.
- 现有的模型在复制AKI研究中完整的环境方面存在局限性.
研究的目的:
- 为了研究CFH对人类脏器官的毒性影响,模拟与败血症相关的AKI.
- 评估临床上可用的小分子对CFH诱导的损伤的保护潜力.
主要方法:
- 人类脏器官被培养使用3D和transwell方法.
- 器官被用CFH治疗了48小时,以诱导损伤.
- 经CFH损伤的器官被与甲酸盐 (维生素C) 或乙氨基联合治疗,以评估保护作用.
主要成果:
- CFH治疗导致管中毒性增加,氧化应激,线粒体碎片化和脏器官中的内皮细胞损伤.
- 同时治疗阿斯科伯酸盐显著降低了CFH诱导的毒性,并保留了内皮细胞.
- 亚酸盐还减轻了线粒体的碎片化,这表明了一种保护机制.
结论:
- CFH诱导人体器官的显著损伤,回顾了败血症相关的AKI的关键特征.
- 亚斯科伯酸盐 (维生素C) 表明对CFH诱导的损伤有保护作用.
- 这些发现突出了 Askorbate 作为一种潜在的治疗剂,用于预防或治疗与败血症相关的 AKI.
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