炎症性肠病与多发性硬化症或霍奇金淋巴瘤同时发生
Amnon Sonnenberg1,2, Hao T Duong3, Daniel J McCarty4
1Section of Gastroenterology, Portland VA Medical Center.
European journal of gastroenterology & hepatology
|November 9, 2023
概括
患有炎症性肠病 (IBD) 的患者患霍奇金淋巴瘤 (HL) 和多发性硬化症 (MS) 的风险增加. 这表明共享的风险因素可能会将这些疾病联系在一起,这需要进一步调查共同的途径.
科学领域:
- 流行病学 流行病学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 流行病学证据表明,霍奇金淋巴瘤 (HL),多发性硬化症 (MS),克罗恩病 (CD) 和性结肠炎 (UC) 的共同危险因素.
- 该假设认为,共同的风险因素可能导致同一患者中这些四种诊断的聚类.
研究的目的:
- 调查HL,MS,CD和UC可能同时发生的情况.
- 确定共享的风险因素是否有助于这些疾病在患者群体中的聚类.
主要方法:
- 使用退伍军人 (2016-2020年) 和医疗保险 (1986-1989) 人口进行了一项病例控制研究.
- 观察到的四种诊断的并发情况与预期的频率进行了比较,使用几率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 在退伍军人中,炎症性肠病 (IBD) 与HL (OR: 1.40) 和MS (OR: 1.34) 有显著关联.
- 在医疗保险患者中,IBD与HL (OR:1.84) 和MS (OR:2.31) 有显著的关联.
- 对于CD和UC单独观察到类似的趋势,经过对混因素进行调整后,结果仍然显著.
结论:
- IBD与HL或MS的同时发生表明其病因或发病过程中存在潜在的共同途径.
- 这些发现支持了影响这些不同疾病发展的共同风险因素的假设.
相关概念视频
Inflammatory Bowel Disease II: Crohn's Disease
259
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
259
Chronic Bowel Disorders: Introduction
458
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
458
Inflammatory Bowel Disease I: Ulcerative Colitis
192
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
192
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
147
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
147
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
338
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
338
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
170
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
170


