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泰国骨髓扩散性瘤患者的临床特征和症状负担

Naritsara Cherdchoo¹, Chantana Polprasert^1,2, Ponlapat Rojnuckarin^1,2

¹Faculty of Medicine Chulalongkorn University, Department of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

Hematology (Amsterdam, Netherlands)

|November 9, 2023

概括

泰国骨髓扩散性瘤 (MPN) 患者经历了显著的症状负担,与脊髓巨变和输血相关的得分更高. 然而,MPN-10得分并不能预测这一群体的生存结果.

科学领域:

血液学血液学血液学
在瘤学瘤学.
生活质量研究研究生命质量研究

背景情况:

骨髓增殖性瘤 (MPNs) 与严重的症状负担有关,影响患者的生活质量.
文化,气候和遗传变异可能会影响全球MPN患者的症状体验和报告.

研究的目的:

为了调查泰国患者诊断出骨髓增殖性瘤 (MPNs) 经历的症状负担.
在泰国队列中,将MPN症状得分与临床结果和人口因素相关联.

主要方法:

从2014年9月到2017年9月,使用MPN-10问卷进行了横截面调查.
分析了来自145名泰国MPN患者的数据,将MPN-10分数与临床参数相关联,包括壮症,疾病并发症和输血需求.

主要成果:

近90%的泰国MPN患者报告了症状,平均MPN-10得分为13.6.
与西方人群相比,原发性骨髓纤维化 (PMF) 的症状负担最高,与基本血小板血 (ET) 和多细胞血真 (PV) 相比,症状负担明显较低.
较高的MPN-10得分与腹壮大和定期输血的需要相关,但与突变状态,疾病进展或死亡率无关.

结论:

MPN-10评分不是泰国MPN患者生存结果的可靠预测指标.
泰国MPN患者的症状负担,特别是ET和PV患者的症状负担,似乎低于西方群体.
识别与较高症状负担相关的因素,如大和输血需求,对于患者管理至关重要.

关键词:

MPN 症状评估表格在MPN-10中使用.在MPN-SAF中使用.MPN MPN 的意思是它们的特性,特点.骨髓扩散性瘤是什么症状负担症状负担血栓形成,脊髓巨变,瘤

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