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具有肠接和肠道穿孔的IgA血管炎的临床特征和危险因素
1Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Journal of paediatrics and child health
|November 9, 2023
概括
像肠塞和肠孔等IgA血管炎 (IgAV) 并发症与年轻年龄,严重的腹痛和先前的胃肠道症状有关. 早期葡萄糖皮质激素治疗可以预防这些严重的IgAV问题.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 类风湿病学 类风湿病学
- 手术并发症 手术并发症
背景情况:
- 肠接是IgA血管炎 (IgAV) 的最常见的外科并发症.
- 肠道穿孔通常伴随着IgAV的入,需要迅速识别和治疗,以避免严重的后果.
- 了解风险因素对于管理IgAV相关的外科紧急情况至关重要.
研究的目的:
- 总结IgA血管炎 (IgAV) 的临床特征,其中包括肠和肠孔.
- 在IgAV患者中确定与这些手术并发症相关的独立风险因素.
主要方法:
- 32名IgAV患者的临床数据的回顾性分析,这些患者患有手术并发症 (输入或穿孔).
- 与160名IgAV儿童的对照组进行比较,这些儿童患有胃肠道 (GI) 干扰,但没有手术并发症.
- 二进制和多变量逻辑回归以确定IgAV相关的肠和肠孔的风险因素.
主要成果:
- 肠道穿孔组在皮肤紫外线之前表现出更频繁的胃肠道症状,长时间的腹痛,较高的疼痛分数 (Wong-Baker) 和较高的白细胞计数,相比于内肠置组.
- 多变量分析确定年龄≤7岁,皮肤紫外线之前的胃肠道症状,严重的腹痛和葡萄糖皮质激素治疗时间作为独立的风险因素.
结论:
- 年龄较小 (≤7岁),严重的腹痛,以及皮肤紫斑之前的胃肠道症状是IgAV中肠和肠孔的重要风险因素.
- 早期启动葡萄糖皮质激素治疗可以作为IgAV中这些手术并发症的预防措施.
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