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基于模型的方法来支持肥胖患者的药物开发:监管视角

Xiaolei Pan1, Li Wang2, Jiang Liu1

  • 1Division of Pharmacometrics, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.

Journal of clinical pharmacology
|November 9, 2023
PubMed
概括

基于模型的药物开发 (MIDD) 有助于了解肥胖如何影响药物的有效性. 对于优化药物开发和对肥胖患者的监管决策,MIDD方法至关重要.

关键词:
临床试验的设计.选择和优化剂量的选择和优化.基于模型的药物开发信息.肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖药物动力学 药物动力学

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