地中海饮食和结直肠腺瘤:观察性研究的系统审查和元分析
Saeede Jafari Nasab1, Cain C T Clark2, Mohammadhasan Entezari1
1Department of Clinical Nutrition, School of Nutrition and Food Sciences, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
概括
坚持地中海饮食 (MED) 与降低结直肠腺瘤 (CRA) 的风险有关. 这种饮食模式可以将CRA风险降低约21%,突出其保护潜力.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 预防医学 预防医学
背景情况:
- 结肠直肠腺瘤 (CRA) 是结肠直肠癌的前体.
- 以前的研究表明,地中海饮食 (MED) 与降低CRA风险之间存在潜在联系,但研究结果不一致.
- 需要进行元分析,以澄清 MED 坚持和 CRA 发展之间的关联.
研究的目的:
- 系统地审查和元分析评估地中海饮食 (MED) 与结直肠腺瘤 (CRAs) 之间的关联的观察性研究.
- 量化与更高的MED遵守相关的CRA风险降低.
主要方法:
- 在主要数据库 (PubMed,Scopus,Google Scholar,Web of Science) 进行了全面的文献搜索,截至2023年5月.
- 包括的研究是观察性的,评估了MED遵守和CRA之间的关系.
- 确定了六项相关研究,并纳入了元分析.
主要成果:
- 对地中海饮食 (MED) 的更高坚持与结直肠腺瘤 (CRAs) 的风险有显著的反向关联.
- 合并的几率比为0.79 (95% CI:0.73-0.85),表明在MED遵守的情况下,CRA风险降低了约21%.
- 根据研究年,性别,设计,国家和暴露的子组分析证实了显著的反向关联.
结论:
- 这一元分析提供了强有力的证据,证明遵守地中海饮食 (MED) 与结直肠腺瘤 (CRAs) 之间的反向关联.
- 加强对MED的坚持可以作为一种保护策略,防止CRA的发展.
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