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味觉功能障碍和阿尔茨海默氏症的关联
1Department of Applied Statistics, Chung-Ang University, Heukseok-dong, Dongjak-gu, Seoul, South Korea.
Rhinology
|November 9, 2023
概括
味觉功能障碍或味觉受损与阿尔茨海默病 (AD) 有关. 客观的味觉测试显示,阿尔茨海默病患者的味觉能力显著下降,但自我报告的味觉能力却没有. 需要进一步的研究来证实这种联系.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 病理学 病理学 病理学
背景情况:
- 化学感官功能障碍,包括味觉障碍,与阿尔茨海默病 (AD) 病原发生有关.
- 虽然在阿尔茨海默病中识别了嗅觉功能障碍,但味觉功能障碍仍未得到充分研究.
- 本综述的重点是评估与健康对照组相比,阿尔茨海默病患者的口味功能障碍.
研究的目的:
- 系统地审查和分析研究研究阿尔茨海默病的味觉功能障碍.
- 为了比较AD患者和健康对照者的客观口味功能测试结果.
- 评估主观味觉评估在诊断阿尔茨海默氏症时的味觉功能障碍方面的可靠性.
主要方法:
- 从2000年1月到2023年2月,在主要数据库 (MEDLINE,Cochrane图书馆,Embase,PubMed) 进行了系统的文献搜索.
- 使用的关键词是"阿尔茨海默病* 和 (味觉或味觉或味觉).
- 包括的研究进行了口味功能测试,并将AD患者与健康对照进行了比较,随后进行了随机效应元分析.
主要成果:
- 包括12项研究,使用各种口味测试 (味道条,磁盘,溶液,问卷).
- 客观测试 (味道条,盘,溶液) 显示,与对照人群相比,阿兹海默病患者的口味功能显著下降.
- 主观问卷没有显示AD患者和对照人群之间味觉功能的显著差异.
结论:
- 客观的味觉功能测试表明,味觉障碍与阿尔茨海默病之间存在强烈的关联.
- 主观的味觉评估可能不能准确地反映AD的味觉缺陷.
- 研究数量有限,缺乏标准化测试,需要进一步的研究来证实口味功能障碍与阿尔茨海默病之间的关系.
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