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Updated: Jul 11, 2025

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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对肺腺癌中具有里程碑意义的分子通路的转录分析导致临床相关的分类,具有潜在的治疗意义

Sara Hijazo-Pechero1,2,3, Ania Alay1,2, David Cordero1,2

  • 1Unit of Bioinformatics for Precision Oncology, Catalan Institute of Oncology (ICO), L'Hospitalet de Llobregat, Barcelona, Spain.

Molecular oncology
|November 9, 2023
PubMed
概括

这项研究根据路径活性定义了七种肺腺癌 (LUAD) 亚型,改善了患者的分层化,超越了基因组学. 这些亚型预测了对化疗和免疫疗法等疗法的生存和反应.

关键词:
免疫疗法 免疫疗法肺部腺癌的癌症.分子路径的分子路径.精确瘤学 精确瘤学转录子类型 转录子类型

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Tumor Progression02:07

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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