梅拉斯玛和后炎性超色素的局部治疗方法
Journal of drugs in dermatology : JDD
|November 9, 2023
概括
局部视网类药物,如tazarotene,在其他选择受到限制时,为色素失调 (如黑色素瘤和炎症后多色素 (PIH)) 提供安全有效的治疗方法.
科学领域:
- 皮肤病学 皮肤病学
- 化品科学 化品科学
背景情况:
- 染色不良,包括黑色素和后炎性多发色素 (PIH),是一种常见的皮肤病问题,特别是在肤色有色的人群中.
- 目前的治疗方法在长期安全性,耐受性或可能恶化多发色素方面存在局限性.
研究的目的:
- 审查针对黑色素和PIH的局部治疗方法.
- 评估视网类药物tazarotene对这些疾病的疗效和安全性.
主要方法:
- 针对黑色素瘤和PIH的局部治疗方法的定性审查.
- 包括来自研究人员发起的tazarotene试验的数据.
主要成果:
- 三重组合化 (HQ) 膏是标准的,但由于安全问题,不能长期使用.
- 局部使用的视网类药物显示出有效性和安全性,耐受性因剂量和配方而异.
- 在24周内,Tazarotene 0.045%聚合物乳液乳液在中度至重度质/PIH患者中显示出良好的疗效,安全性和耐受性.
结论:
- 有多种局部治疗方法可以治疗色素失调,但许多方法缺乏可靠的疗效数据或存在安全性/耐受性问题.
- 视网类药物,以tazarotene为例,为治疗黑色素和PIH提供了一个有前途,安全和有效的治疗选择.
相关概念视频
Skin Cancer
4.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.2K
Changes in Skin Color: Clinical Perspectives
2.0K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
2.0K
Pigmentation
2.4K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
2.4K


