功能化的Fe-Doped碳点显示双重氨酸消费以扩大铁死,用于增强癌症治疗
Mingyue Zhou1, Ziwei Yang1, Tianpeng Yin1
1State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease, Macau University of Science and Technology, Macau 999078, China.
ACS applied materials & interfaces
|November 9, 2023
概括
这项研究引入了FeCDs纳米粒子,通过消耗谷和放大氧化应激,有效诱导新型癌症治疗方法ferroptosis. 这种方法克服了多药性耐药性,并显示出显著的抗瘤疗效.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 传统的癌症疗法往往由于多药性耐药性而失败.
- 亡诱导的细胞死亡是一种常见的机制,但铁亡提供了一个替代方案.
- 减少细胞内谷氨 (GSH) 是触发铁亡的关键,但目前的方法有限.
研究的目的:
- 开发一种基于纳米粒子的新策略来诱导铁灭.
- 设计具有增强GSH消耗能力的纳米粒子.
- 克服现有的诱导铁灭的治疗方法的局限性.
主要方法:
- 具有双重GSH消耗能力的Fe3+修饰的l-histidine来源的碳点 (FeCD) 的构建.
- 将FeCD封装成一种由酸触发的降解材料 (FeCDs@PAE-PEG).
- 对FeCDs@PAE-PEG用于自我放大内氧化应激和铁灭诱导的评估.
主要成果:
- FeCDs表现出增强的GSH消耗能力,与H2O2反应产生基基 (•OH).
- FeCDs@PAE-PEG显示有针对性的输送和增强的GSH消耗和铁积累.
- 这种协同策略在体外和体内表现出显著的铁致死诱导能力和抗瘤功效.
结论:
- FeCDs@PAE-PEG代表了一种新的协同自放大疗法,用于铁死.
- 这种方法有效地克服了多药性耐药性,并提高了抗瘤功效.
- 开发的纳米粒子在癌症治疗中具有很大的临床转化潜力.
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