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相关概念视频

Tumor Immunotherapy01:27

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In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells
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来自食道癌细胞的小细胞外囊泡通过sEV-PDL1减少循环Tfh/Tfr,促进免疫抑制.

Zijie Li1, Yuehua Zhang2, He Hao3

  • 1Hebei Medical University, Shijiazhuang, 050011, Hebei, China.

Cancer immunology, immunotherapy : CII
|November 9, 2023
PubMed
概括

在食道癌 (EC) 中,表达PD-L1 (sEV-PDL1) 的小细胞外囊泡破坏Tfh/Tfr细胞平衡,促进免疫逃生. 准sEV-PDL1可能会恢复这种平衡,并提供一种新的EC疗法.

关键词:
食道癌是食道癌的一个类型.毛囊辅助T细胞 毛囊辅助T细胞毛囊调节性T细胞 毛囊调节性T细胞免疫抑制是一种免疫抑制.sEV-PDL1 的情况.

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科学领域:

  • 免疫学 免疫学 免疫学
  • 在瘤学瘤学.
  • 细胞外囊泡研究研究

背景情况:

  • 食道癌 (EC) 的进展与免疫逃避有关.
  • 表达编程死亡带1 (sEV-PDL1) 的小细胞外囊 (sEV) 有助于瘤免疫逃生.
  • 循环毛囊辅助T细胞 (Tfh) 和毛囊调节T细胞 (Tfr) 之间的不平衡与各种癌症有关.

研究的目的:

  • 研究EC衍生的sEV-PDL1在调节循环Tfh和Tfr细胞中的作用.
  • 阐明sEV-PDL1影响Tfh/Tfr细胞平衡和功能的机制.
  • 在欧洲共同体探索针对sEV-PDL1的治疗潜力.

主要方法:

  • 流细胞测量检测循环Tfh和Tfr细胞在EC患者和健康捐赠者 (HDs).
  • 从EC中分离和描述sEVs.
  • 在体外共同培养试验中,使用具有sEVs的天真CD4+T细胞进行测定,以评估Tfh和Tfr细胞分化,表型和功能.
  • 对细胞因子 (IL-21,IFN-γ,IL-10) 的分析.
  • 对抗PDL1抗体治疗效果的评估.

主要成果:

  • 与HD患者相比,EC患者的循环Tfh较低,循环Tfr较高,Tfh/Tfr比率较低.
  • 在EC患者中观察到sEV-PDL1水平升高,与Tfh/Tfr比率负相关.
  • 在体外,sEV-PDL1抑制了Tfh扩张,促进了Tfr扩张和免疫抑制功能,并改变了细胞因子的产生.
  • 反PDL1抗体治疗逆转了sEV-PDL1.1的影响.

结论:

  • 通过破坏循环中的Tfh/Tfr平衡,EC衍生的sEV-PDL1在免疫抑制中发挥着关键作用.
  • sEV-PDL1促进Tfr细胞的扩张和功能,同时抑制Tfh细胞.
  • 向sEV-PDL1代表了一种有前途的治疗策略,以恢复食道癌的免疫平衡.