基于光倍增器的PET与传统PET之间的小型结构中生理FDG吸收的比较研究
Shiro Watanabe1,2, Kenji Hirata3,4,5, Keiichi Magota6
1Department of Diagnostic Imaging, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita-Ku, Sapporo, Hokkaido, 060-8638, Japan.
Annals of nuclear medicine
|November 9, 2023
概括
基于光倍增器的PET/CT (SiPM-PET/CT) 在小型结构中比传统的PET/CT (cPET/CT) 显示出更高的生理F-氧糖 (FDG) 吸收. 对于cPET/CT的值可能会导致SiPM-PET/CT的错误阳性.
科学领域:
- 核医学就是核医学.
- 医疗成像医学成像
- 放射化学 放射化学是指辐射化学.
背景情况:
- 基于光倍增器的正电子发射断层扫描/计算机断层扫描 (SiPM-PET/CT) 与传统的PET/CT (cPET/CT) 相比,提供更高的空间分辨率.
- 在小型解剖结构中对生理性F-氧糖 (F-fluorodeoxyglucose,FDG) 的吸收进行准确的评估,对于区分良性发现与恶性病变至关重要.
研究的目的:
- 直接比较SiPM-PET/CT和cPET/CT之间在小结构中的生理FDG积累的成像特征.
- 评估已建立的SUVmax值的适用性,以区分SiPM-PET/CT中的生理和病理吸收.
主要方法:
- 对19名头部和部恶性瘤患者进行了对比,这些患者接受了SiPM-PET/CT和cPET/CT扫描.
- 标准化吸收值 (SUVmax) 被测量在垂体腺,食管胃结,上腺,脊髓腰部扩大和脊柱上腺.
- 计算了目标与肝脏的比率 (TLR) 和目标与血液的比率 (TBR),以评估相对于背景水平的吸收.
主要成果:
- 与cPET/CT相比,SiPM-PET/CT对所有测量的生理吸收目标的SUVmax值显著更高.
- 在所有目标中,SiPM-PET/CT中,目标与肝脏的比率 (TLR) 显著更高.
- 针对大多数目标的SiPM-PET/CT中,目标与血液的比率 (TBR) 也显著更高.
结论:
- 在小型解剖结构中,生理FDG吸收在SiPM-PET/CT上明显高于cPET/CT.
- 使用cPET/CT来区分病理和生理吸收的现有值可能会导致更高的假阳性发现率,当应用到SiPM-PET/CT成像时.
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