维生素D与埃及患者冠状动脉疾病之间的关系
Magdy Algowhary1, Ahmed Farouk2, Heba E M El-Deek3
1Department of Cardiovascular Medicine, Assiut University Heart Hospital, Assiut University, Asyut, 71516, Egypt. magdyalgowhary@aun.edu.eg.
概括
低维生素D (VD) 水平与埃及人的冠状动脉疾病 (CAD) 有关. 这项研究将静脉疾病确定为CAD的非传统风险因素,特别是在多个病变动脉的情况下.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 关于维生素D (VD) 水平与冠状动脉疾病 (CAD) 之间的关联,存在相互矛盾的结果.
- 之前的研究已经在VD和CAD之间的联系上产生了不一致的结果.
- 在埃及人群中,静脉疾病和动脉样性CAD之间的关系需要进一步研究.
研究的目的:
- 调查埃及人的维生素D (VD) 水平与动脉样硬化冠状动脉疾病 (CAD) 之间的联系.
- 确定VD是否是该人群中CAD的独立预测因素.
- 探索静脉疾病水平与冠状动脉样硬化的程度之间的相关性.
主要方法:
- 预期招募188名连续CAD患者,通过心脏导管诊断.
- 与131名健康对照个体进行比较.
- 测量所有参与者的血清维生素D (VD) 水平.
主要成果:
- 与对照组 (42.0 ng/mL) 相比,CAD患者的VD中位数显著降低 (14.65 ng/mL).
- 静脉动脉病的水平与患病的冠状动脉数量和脂质概况有显著的相关性 (p < 0.001).
- 低静脉疾病被确定为CAD的独立预测因子 (OR 1.22,p = 0.003) 并与多血管疾病有关.
结论:
- 低维生素D (VD) 应该被认为是埃及人冠状动脉疾病 (CAD) 的非传统风险因素.
- 低静脉疾病和冠状动脉样硬化之间存在显著的相关性,特别是在患有多血管疾病的患者中.
- 这些发现凸显了埃及人心血管健康中风病状况的重要性.
相关概念视频
01:26Coronary Artery Disease IV: Preventive Measures
23
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
23
01:30Coronary Artery Disease I: Introduction
17
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
17
01:23Role of Skin in Vitamin D Synthesis
5.2K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.2K
01:30Coronary Artery Disease III: Clinical Manifestations
12
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
12
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
18
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
18
01:26Coronary Artery Disease II: Pathophysiology
12
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
12