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Updated: Jul 11, 2025

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使用非线性混合效应方法的双变混合隐藏马尔科夫模型对抗药物抗体动态的表征

Ari Brekkan1, Rocío Lledo-Garcia2, Brigitte Lacroix3

  • 1Department of Pharmacy, Uppsala University, Box 580, Uppsala, SE-75123, Sweden.

Journal of pharmacokinetics and pharmacodynamics
|November 9, 2023
PubMed
概括

生物疗法可以触发抗药抗体 (ADA). 一个新的混合隐藏马尔科夫模型 (MHMM) 识别了ADA生产,提供了一种更独立于测试的方法来了解药物处置并最大限度地降低影响.

关键词:
反药物抗体的形成.当然lizumab pegol可以使用.这是一种抗TNF的药物.隐藏的马尔科夫模型

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