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综合突神经病理和艾滋病毒相关的神经认知障碍之间的关系是由认知储备调节的
Arin Fisher1, David J Moore1, Andrew J Levine2
1Department of Psychiatry, University of California San Diego, La Jolla, CA, 92037, USA.
Journal of neurovirology
|November 9, 2023
概括
认知储备可以保护艾滋病毒感染者免受神经退行相关的认知衰退. 高认知储备缓冲了中度的神经退行,但不是严重的神经退行.
科学领域:
- 神经科学是一个神经科学.
- 神经病理学神经病理学
背景情况:
- 与艾滋病毒相关的神经认知障碍 (HAND) 是一个重大问题.
- 了解改变艾滋病毒感染者的认知衰退 (PWH) 的因素至关重要.
研究的目的:
- 研究认知储备在PWH中神经退行和认知功能之间的关系中所起的调节作用.
主要方法:
- 在67个PWH中对突触质神经退行 (synaptophysin,MAP2) 的死后脑组织分析.
- 认知储备通过使用宽范围成就测试-4阅读子测试 (WRAT4) 来评估.
- 认知功能通过15个认知测试的全球T-score测量,测量死亡前一年内的认知功能.
主要成果:
- 在具有低认知储备的PWH患者中,中度神经退行与较小的神经退行相比,与较差的认知有关.
- 在具有高认知储备的PWH中,中度神经退行表明认知能力与最小神经退行相当,比严重的神经退行更好.
- 高度的认知储备似乎缓冲了在存在中度,但不严重的神经退行症时的认知障碍.
结论:
- 认知储备在缓解PWH认知障碍方面发挥着重要作用.
- 认知储备的保护作用取决于神经退行症的严重程度.
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