在英国利物浦,参与者对一种新的基于社区的呼吸纵向采样方法的看法和经验:混合方法可行性研究
Esther L German1, Helen M Nabwera1,2, Ryan Robinson1,3
1Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
"FAMILY Micro"研究发现,在家庭中对呼吸道病原体进行最小侵入性自我采样是可行的. 虽然大多数成年人和年长的孩子都能很好地容忍采样,但年幼的孩子更容易感到不舒服,这突出了未来研究设计改进的领域.
科学领域:
- 微生物学 微生物学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 纵向,以社区为基础的采样对于了解呼吸道病原体的流行和传播至关重要.
- 对于长期的,以家庭为基础的研究,需要最少的侵入性采样方法.
研究的目的:
- 探索参与者对为期6个月的纵向,基于社区的抽样研究 (FAMILY Micro) 的经验和意见.
- 评估家庭环境中对呼吸道病原体进行自我采样的可行性和可接受性.
主要方法:
- 一种混合方法的方法,结合了定量问卷和定性退出访谈.
- 收集关于疼痛,不适和口腔,鼻腔和手部微生物群采样时间的定量数据.
- 定性访谈探讨了参与者的经验和改善研究的建议.
主要成果:
- 大多数成年人和5岁以上的儿童报告说,疼痛和不适是最小的.
- 较年轻的儿童 (≤5岁) 经历了更可变的疼痛和不适.
- 家庭发现自取样很简单,他们更喜欢合成吸收矩阵鼻抽样而不是鼻抽样.
- 挑战包括将采样纳入繁忙的时间表;适当的冷藏和及时采样是很重要的.
- 消息应用程序对于参与者的参与是有效的.
结论:
- 在家庭环境中,在家进行最小侵入性自取样是可行的.
- 研究设计应考虑特定年龄的耐受性,特别是对于年幼的儿童.
- 存储和取货时间表等后勤因素对于成功的社区研究至关重要.
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