心脏和全身性硬化症-来自全国队列研究的研究结果
Alexis F Guédon1,2, Fabrice Carrat2,3, Luc Mouthon4
1Sorbonne Université, APHP, Service de Médecine Interne, Département Hospitalo-Universitaire Inflammation-Immunopathologie-Biotherapie (DMU i3), Paris, France.
Rheumatology (Oxford, England)
|November 9, 2023
概括
在系统性硬化症 (SSc) 中,心脏参与是一个主要问题. 这项研究揭示了其患病率,扩散性SSc等危险因素,以及其与SSc患者死亡率增加的关联.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 流行病学 流行病学
背景情况:
- 心脏参与是系统性硬化症 (SSc) 死亡的主要原因.
- 与SSc相关的心脏病的患病率和预后影响尚未得到充分确立.
- 了解这些因素对于患者的管理和结果至关重要.
研究的目的:
- 调查SSc相关心脏干扰的患病率和预后.
- 确定全国性SSc队列中心脏病的发病率和风险因素.
- 分析SSc.中各种心脏病的生存影响.
主要方法:
- 利用了法国SSc国家数据库的多中心前性研究的数据.
- 专注于确定SSc相关的心脏干扰,其发生率和相关风险因素.
- 对一组SSc患者进行了存活分析,其中包括有或没有心脏参与的SSc患者.
主要成果:
- 在3528名SSc患者中,10.9%的患者在基线时患有心脏病,与扩散亚型和心血管风险因素相关.
- 与SSc相关的心脏干扰增加了死亡风险;在与SSc相关的心脏干扰,缺血性心脏病或肺动脉高血压之间没有发现显著的生存差异.
- 五年事件率:11.15%的SSc相关心脏干扰,2.49%的减少LVEF,5.84%的透析功能障碍,和3%的心周炎. 扩散性SSc亚型是SSc相关心脏干扰和心周炎的危险因素;女性性别与较少的透心功能障碍有关.
结论:
- 这项大规模研究澄清了SSc相关心脏干扰的发病率和预后负担.
- 分散的SSc亚型和女性性别被确定为特定心脏结果的显著风险因素.
- 需要进一步的研究来评估治疗对SSc.心脏结果的影响.
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