实体器官移植接受者癌症发病率的性别差异
Sarah S Jackson1, Ruth M Pfeiffer1, Mei-Chin Hsieh2
1Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Journal of the National Cancer Institute
|November 9, 2023
概括
男人患癌症的风险高于女性,但移植受体的免疫抑制可以缩小某些癌症的差距. 这表明免疫监测的作用,在女性移植患者中可能会减少.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 移植 移植 移植 移植
背景情况:
- 在大多数共享的解剖部位上,男性的癌症风险比女性高2-3倍.
- 这种差异可能归因于女性加强免疫监测.
- 这项研究调查了这些性别差异是否在免疫功能低下的成年人中持续存在.
研究的目的:
- 为了确定是否基于性别的癌症发病率差异在免疫功能低下的成年人中持续存在.
- 为了比较男性和女性固体器官移植接受者之间的癌症发病率.
- 评估免疫抑制对性别特异性癌症风险的影响.
主要方法:
- 利用了移植癌症匹配 (TCM) 研究 (1995-2017) 的数据.
- 在移植受体 (IRRTransplant) 和一般人口 (IRRGP) 中估计的男性对女性发病率比率 (IRRs).
- 用Poisson回归和千平方测试进行统计分析.
主要成果:
- 分析了343,802例固体器官移植 (61.4%的男性,38.6%的女性).
- 在男性中观察到过多的癌症发病率,但对于唇部,胃,结肠直肠,肝脏,脏,膀,卡波西肉瘤和非霍奇金淋巴瘤的癌症,性别差异减弱.
- 对于几个癌症部位,移植受体的男性对女性的IRR低于一般人群.
结论:
- 男性实体器官移植受体的癌症发病率高于女性.
- 移植受体中男性与女性癌症比率的减弱表明免疫监测的重要性.
- 移植后的免疫抑制可能会减少在一般人群中女性观察到的癌症保护优势.
更多相关视频
10:11Using Quantitative Real-time PCR to Determine Donor Cell Engraftment in a Competitive Murine Bone Marrow Transplantation Model
Published on: March 7, 2013
15.4K
08:05Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
Published on: March 17, 2020
7.9K
相关概念视频
01:28Kidney Transplant I: Introduction
14
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
14
01:24Tissue Transplantation
376
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
376
01:22Bone Marrow Sampling and Transplants
339
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
339
01:26Kidney Transplant II: Surgical Procedure
20
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
20