我如何治疗耐火性和复发性急性髓性白血病
Felicitas Thol1, Hartmut Döhner2, Arnold Ganser1
1Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Blood
|November 9, 2023
概括
耐药性/复发性急性髓性白血病 (AML) 仍然具有挑战性,在阿扎西提丁/维内托克拉克斯后的选择有限. 新型疗法和临床试验对于改善这些难以治疗的AML患者的治疗结果至关重要.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 大多数急性髓性白血病 (AML) 患者尽管接受了新型疗法,但仍患有耐药/复发性 (R/R) 疾病.
- 目前对R/RAML的治疗方法是特定于子组的,这突显了需要更广泛的治疗策略的需要.
- 全基性造血细胞移植 (HCT) 提供了一个潜在的治愈选择,不断发展的方法针对可测量的残留疾病 (MRD).
研究的目的:
- 审查R/R AML.目前的治疗格局.
- 讨论新兴的向疗法和组合策略.
- 强调临床试验招生对R/RAML的重要性.
主要方法:
- 目前文献和FDA/EMA批准的R/RAML治疗方法的综述.
- 在HCT之前讨论救援化疗和向治疗方法.
- 探索新型药物,包括脑膜抑制剂,CD47抗体和组合疗法.
主要成果:
- 吉尔特里尼布已被批准用于复发的FLT3突变AML;IDH1/2向治疗仅获得FDA批准.
- 在阿扎西蒂丁/韦内托克拉克斯 (AZA/VEN) 后,R/R AML 的结局不佳,现有向治疗的结果不令人满意.
- 目前正在进行的研发包括脑膜抑制剂,CD47抗体和三重AZA/VEN组合,尽管骨髓抑制存在挑战.
结论:
- R/R AML带来了重大的治疗挑战,需要探索新药和加强治疗.
- 向疗法和免疫疗法显示出希望,但需要进一步的研究和优化.
- 临床试验对于推进R/RAML治疗模式至关重要.
相关概念视频
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Bone Marrow Sampling and Transplants
339
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
339
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Stem Cell Therapy for Tissue Regeneration
4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K


