与COVID相关的压力因素和内化症状之间的关系:基于性别的神经内分泌风险概况
Jose M Guzman1, Montana H Boone1, Gabriela L Suarez1
1Department of Psychology, University of Michigan, Ann Arbor, MI, USA.
Psychoneuroendocrinology
|November 9, 2023
概括
COVID-19 流行病增加了压力和内化障碍,特别是在女性中. 神经内分泌的差异,特别是脱水氨 (DHEA) 和皮质醇的比例,对男性和女性的这些与压力相关的结果有不同的影响.
科学领域:
- 神经内分泌学神经内分泌学
- 精神病学是一个精神病学.
- 青少年健康 青少年健康
背景情况:
- COVID-19大流行加剧了压力和内化障碍,女性受到了不成比例的影响,突出了与压力有关的障碍中的性别差距.
- 在青春期出现压力脆弱性的性别差异,与神经内分泌变化有关,特别是涉及下丘脑-垂体-上腺 (HPA) 轴荷尔蒙皮质醇和脱水氨 (DHEA).
- 虽然皮质醇被广泛研究,但DHEA的神经保护作用及其与皮质醇在应激反应和内化障碍中的相互作用需要进一步研究,特别是关于性别特异性关联.
研究的目的:
- 为了前性地检查青春期神经内分泌反应 (DHEA和皮质醇) 与年轻成人COVID-19大流行期间内化症状之间的关系.
- 调查COVID相关压力与内化症状之间的关系中的潜在性别差异.
- 探索DHEA-皮质醇比率在与COVID相关的压力和男性和女性内化症状之间的关系中起的调节作用.
主要方法:
- 175名主要是黑人,低社会经济地位的参与者的前性队列研究.
- 15岁时对社会评估冷压任务 (SECPT) 的神经内分泌反应的评估.
- 在21岁的COVID-19大流行期间测量内部化症状,控制15岁的基线内部化症状.
主要成果:
- 与COVID相关的压力和内化症状之间的关联在女性中与男性相比并没有显著强烈.
- 较低的脱水氨-皮质醇比率与女性的COVID相关压力和内化症状之间的关系较弱有关.
- 较高的脱水氨-皮质醇比率与男性的COVID相关压力和内化症状之间的关系较弱有关.
结论:
- 在神经内分泌调节压力和内化症状方面存在性别差异.
- 在调解压力对男性和女性心理健康结果的影响方面,DHEA-皮质醇比率起着不同的作用.
- 这些发现表明,不同的神经内分泌通路会使年轻男性和女性面临与压力相关的疾病的风险或保护.
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