相关实验视频

Updated: Jul 11, 2025

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

阻断IL-6R可以防止早产和新生儿不良后果

Marcelo Farias-Jofre¹, Roberto Romero², Jose Galaz¹

¹Pregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS), Bethesda, MD, USA; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA; Division of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.

|November 9, 2023

概括

用aIL-6R阻断IL-6受体 (IL-6R) 可以预防早产和新生儿死亡率,这些都是由无菌胚胎内炎症 (SIAI) 引起的. 这种产前治疗改善了新生儿的生存,生长,神经发育和肠道免疫力.

科学领域:

生殖生物学生殖生物学
免疫学免疫学免疫学
新生儿医学新生儿医学

背景情况:

无菌胚胎内炎症 (SIAI) 是自发早产的一个关键因素,这种情况缺乏有效的治疗方法.
介素-6 (IL-6) 和介素-1α (IL-1α) 参与了SIAI的炎症过程.

研究的目的:

调查IL-6和IL-1α在SIAI诱导的早产中的作用.
评估IL-6受体 (IL-6R) 阻断使用抗IL-6R抗体 (aIL-6R) 预防早产和新生儿不良后果的治疗潜力.

主要方法:

分析人类蛋白质组和scRNA-seq数据,以了解SIAI中的IL-6和IL-1α作用.
通过内IL-1α注射进行SIAI诱导的早产的小鼠模型的开发.
评估aIL-6R作为产前治疗,评估胎儿大脑氧化应激 (QUEST-MRI),孕产妇/胎儿/新生儿炎症,新生儿结局和肠道微生物组.

主要成果:

在小鼠体内注射IL-1α模仿了SIAI,显著增加了早产和新生儿死亡率.
产前aIL-6R治疗有效地取消了IL-1α诱导的早产和降低了新生儿死亡率.
通过减少炎症,aIL-6R治疗改善了新生儿的存活率,生长,神经发育和肠道免疫平衡.

结论:

阻断IL-6R是一种有前途的治疗策略,用于治疗SIAI.
产前IL-6R阻塞可以预防早产和减轻与SIAI相关的新生儿不良结果.

关键词:

这是一个警报器.它们的IL-1α.微生物组是一个微生物组.怀孕怀孕怀孕怀孕过早生育过早生育无菌的胚胎内炎症.

更多相关视频

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

相关概念视频

Rh Blood Group

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.

Development of Immunocompetence

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...