超越症状:通过多维患者报告结果测量来个性化巨细胞动脉炎护理
Y El Miedany1, M El Gaafary2, M Toth3
1Professor Canterbury Christ Church University, England; H. Senior Clinical Lecturer, King's College London, England.
Seminars in arthritis and rheumatism
|November 9, 2023
概括
一个新的问卷,巨细胞动脉炎患者报告的结果测量 (GCA-PROMs) 已经开发出来. 这种可靠和有效的工具评估了GCA患者的病情.
科学领域:
- 类风湿病学 类风湿病学
- 临床试验 临床试验
- 患者报告的结果
背景情况:
- 巨细胞关节炎 (GCA) 是50岁以上人群中最常见的系统性血管炎.
- 现有研究表明,针对GCA.的疾病特异性患者报告结果措施 (PROMs) 存在缺陷.
研究的目的:
- 评估新开发的,针对GCA的疾病特异性PROM的有效性,可靠性和响应能力.
- 建立一个强大的工具来评估患者在巨细胞动脉炎的经验.
主要方法:
- GCA-PROMs问卷是根据OMERACT框架和FDA指导方针设计的.
- 通过认知面试生成项目池,随后进行患者和专家跨学科选择.
- 进行了Rasch分析和内部一致性可靠性分析.
主要成果:
- 在54名GCA患者中,GCA-PROMs问卷显示出高可靠性 (标准化α 0.878-0.983).
- 在GCA-PROM (功能障碍,QoL) 和既定措施 (HAQ,EQ-5D,p<0.01) 之间发现了显著的相关性.
- 功能障碍和QoL的变化与疾病活动和治疗反应有显著的相关性 (p<0.01).
结论:
- GCA-PROMs是评估巨细胞动脉炎患者的可靠和有效工具.
- 该工具支持量身定制的患者管理策略,考虑个体风险因素,偏好和并发症.
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