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在基于性别的社区疫苗接种努力后,非疫苗向HPV的生态多样性概况

Ville N Pimenoff¹, Penelope Gray², Karolina Louvanto³

¹Department of Clinical Science, Intervention and Technology - CLINTEC, Karolinska Institutet, Stockholm, Sweden; Biobank Borealis, Faculty of Medicine, University of Oulu, Oulu, Finland; Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland; Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland.

Cell host & microbe

|November 9, 2023

概括

人类乳头瘤病毒 (HPV) 疫苗接种在8年内增加了非向性HPV类型的多样性. 这种病毒生态转变可能会影响未来的宫癌查策略.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
公共卫生公共卫生

背景情况:

人类乳头瘤病毒 (HPV) 疫苗接种对非向型HPV的长期影响尚不清楚.
了解病毒生态变化对于评估疫苗接种计划影响至关重要.

研究的目的:

评估性别中立和仅针对女孩的HPV16/18疫苗接种对非向型HPV型的生态多样性的长期影响.
为了评估HPV多样性的变化,疫苗接种后4年和8年.

主要方法:

33个社区的长度研究随机分为性别中立的HPV疫苗接种,仅限女孩的HPV疫苗接种或没有疫苗接种.
在出生队列中的参与者中,多种HPV类型的宫-阴道采样和基因定型.
在8年的随访期间,对HPV类型的社区级生态多样性估计.

主要成果:

性别中立的HPV疫苗接种,赋予更强的群体免疫力,在接种疫苗后4至8年显著增加HPVα多样性 (p=1.1×10−8).
这种多样性的增加发生在疫苗向型HPV类型 (16/18) 在接种疫苗的社区中的清除.
非向性HPV类型似乎占据了由疫苗向性类型空置的生态.

结论:

人口级别的HPV疫苗接种可以导致非疫苗向的HPV类型的多样性增加.
这种生态转变可能需要对未来的宫癌查计划进行调整.
观察到的变化不太可能阻碍世界卫生组织消除子宫癌的目标.

关键词:

社区随机化社区随机化淘汰消除淘汰淘汰基于性别的疫苗接种战略人类乳头瘤病毒人类乳头瘤病毒纵向后续研究是纵向后续研究.利基专业职业利基专业职业替换型号替换型号替换型号替换型号病毒生态学病毒生态学

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