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通过SARS-CoV-2的RAGE参与使单细胞感染成为可能,并为COVID-19的严重程度奠定了基础

Roberta Angioni¹, Matteo Bonfanti², Nicolò Caporale³

¹Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy; Fondazione Istituto di Ricerca Pediatrica - Città Della Speranza, 35127 Padova, Italy.

Cell reports. Medicine

|November 9, 2023

概括

先进的糖化最终产品 (RAGE) 的受体是严重COVID-19的关键途径. RAGE使SARS-CoV-2病毒能够感染单细胞,从而导致疾病的严重程度.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
分子生物学分子生物学

背景情况:

由SARS-CoV-2引起的COVID-19大流行,带来了持续的医疗和社会经济挑战.
了解COVID-19病变的分子机制对于管理疾病严重程度和长期后果至关重要.

研究的目的:

为了研究COVID-19病变发生的分子基础.
在疾病的过程和严重程度上分析单细胞分辨率时的免疫反应.
确定导致COVID-19严重程度的关键分子通路.

主要方法:

在COVID-19不同阶段和严重程度的患者免疫反应的单细胞分析.
在体外实验中使用THP1细胞来研究单细胞-病原体相互作用.

主要成果:

在COVID-19患者中确认了特定细胞亚群的失调.
鉴定了与疾病严重程度相关的单细胞中先进的糖化最终产品 (RAGE) 途径的受体的激活.
证明单细胞通过RAGE. 通过SARS-CoV-2 S1受体结合域 (RBD) 结合.
表明RAGE-Spike相互作用可以促进SARS-CoV-2的单细胞感染.

结论:

雷格是SARS-CoV-2的功能性受体.
RAGE-Spike相互作用在COVID-19病变发生过程中发挥着重要作用.
准RAGE途径可能是减轻COVID-19严重性的策略.

关键词:

在 COVID-19 疫情中,愤怒的愤怒愤怒的愤怒这就是SARS-CoV-2病毒.疾病的严重程度.药物重用是为了改变药物的用途.纵向分析是指纵向分析的方法.单细胞 (Monocytes) 是一种单细胞.一个单细胞多细胞的奥米克.

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