甲基荷胺诱导的高血压危机:当前的见解和管理
Matthew A Nazari1, Rockyb Hasan1, Mark Haigney2
1Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
The lancet. Diabetes & endocrinology
|November 9, 2023
概括
发病于色染色细胞瘤和状细胞瘤的甲基胺诱导的高血压危机是可以治疗的. 早期诊断和灵活的治疗策略可以减轻严重的并发症并改善患者的治疗结果.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 在瘤学瘤学.
背景情况:
- 色细胞瘤和偏角细胞瘤 (PPGLs) 引起由甲醇胺诱导的高血压 (CIH) 危机.
- CIH危机带来诊断挑战,缺乏明确的治疗方案,往往需要多学科的护理.
研究的目的:
- 为诊断和管理CIH危机提供基于证据的指导.
- 概述灵活的治疗方法,考虑到药物的可用性和提供者的偏好.
主要方法:
- 审查现有证据和60年的临床经验.
- 分析了超过2600名PPGL患者和100名NIH患者的CIH危机数据.
主要成果:
- CIH危机可能会导致严重的并发症,如动脉节律失常和目标器官损伤.
- 由于混因素,生化诊断可能很困难.
- 现有的药物可以有效地管理CIH危机及其并发症.
结论:
- 对CIH危机的有效干预可以通过可用的药物实现.
- 灵活,定制的治疗策略可以减轻与PPGL相关的CIH危机患者的发病率和死亡率.
相关概念视频
Hypertension V: Nursing Management
10
The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
10
Hypertension I: Introduction
14
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
14
Hypertension and Regulation of Blood Pressure
2.1K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
2.1K
Adrenergic Agonists: Therapeutic Uses
818
Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
818
Hypertension III: Clinical Manifestations and Diagnostic Studies
15
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
15
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
438
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
438


