在急性睡眠不足后,工作记忆网络中的功能连接发生变化
Sitong Feng1, Hao Yao2, Sisi Zheng1
1The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.
Neuroscience
|November 9, 2023
概括
急性睡眠不足通过改变大脑连接来损害工作记忆 (WM). 结果显示,在睡眠丧失后,特定的大脑区域显示异常激活和功能连接变化,影响WM性能.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
背景情况:
- 急性睡眠剥夺 (SD) 对工作记忆 (WM) 有负面影响.
- 以前的功能性磁共振成像 (fMRI) 研究显示,SD后大脑功能变化存在不一致的结果.
- 与SD后WM衰退相关的异常大脑功能的融合模式需要识别.
研究的目的:
- 为了确定与急性睡眠剥夺后工作记忆下降相关的异常大脑功能的一致模式.
- 使用元分析和静态fMRI数据构建一个工作记忆网络.
- 为了研究功能连接变化和睡眠剥夺后工作记忆表现之间的关系.
主要方法:
- 基于坐标的激活概率估计 (ALE) 对SD和WM任务状态fMRI研究的元分析.
- 休息状态fMRI扫描在26名健康受试者在SD前24小时和24小时后进行.
- 在已识别的WM网络中计算功能连接 (FC) 并与WM性能相关联.
主要成果:
- 分析显示,在WM任务中SD后的头尾叶和叶叶,前叶和后 cingulate 持续低活化.
- 在左舌环,,叶和状环中观察到一致的过度激活.
- 在特定区域 (例如,左下垂和右下垂) 之间发现了增加的FC,与WM性能受损负相关.
结论:
- 工作记忆网络中的功能连接的改变是急性睡眠剥夺后WM下降的潜在机制.
- 该研究确定了受SD影响的特定大脑区域和连接模式.
- 这些发现有助于理解睡眠丧失后认知缺陷的神经生物学基础.
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