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Updated: Jul 11, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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神经生存因子TAFA2通过与ADGRL1结合并激活cAMP/PKA/CREB/BCL2信号通路来抑制细胞亡

Hui Liang1, Ling Yun Tang1, Hao Yang Ge1

  • 1State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine, Rui-Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Life sciences
|November 9, 2023
PubMed
概括

研究人员确定ADGRL1是TAFA2的受体,TAFA2是中枢神经系统的细胞因子. 这种相互作用激活了一个信号通路,这对于神经元的生存和预防细胞死亡至关重要,为神经系统疾病提供了潜在的治疗点.

关键词:
在FAM19A2中,FAM19A2是FAM19A2的第二种类型.在GPCR中,GPCR是指GPCR.敲进的小鼠 敲进的小鼠莱克类域名 莱克类域名体-受体相互作用的相互作用

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