相关实验视频
Updated: Jun 18, 2026
10:33
Generation of Alginate Microspheres for Biomedical Applications
Published on: August 12, 2012
20.8K
用微流体技术制备pH敏感的基于酸盐的水凝,用于肠道向药物输送
Shishuai Qiao1, Weinan Chen2, Xiaoguang Zheng1
1School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China.
International journal of biological macromolecules
|November 9, 2023
概括
使用微流体制备的pH敏感的水凝微球可以在小肠中向药物输送. 酸微囊在模拟的肠液中显示出出色的稳定性和受控释放特征.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 微流体技术技术 微流体技术
背景情况:
- 水凝微球在药物输送方面具有优势,包括小颗粒大小,生物相容性和稳定性.
- 向向小肠药物输送需要能够承受胃环境的pH敏感材料.
研究的目的:
- 使用微流体技术开发pH敏感的水凝微球,用于在小肠中向药物输送.
- 为了研究控制水凝微球大小和印米的负荷.
- 为了评估水凝微囊在模拟胃和肠液中的释放特性.
主要方法:
- 构建同轴双通道和改进的同轴三通道微流体芯片.
- 分析流量和断裂阶段 (雷利-普拉托,压差,切削力) 以控制微球大小.
- 准备和表征单层和核心外水凝微囊装载Indometacin.
- 在实验室模拟释放实验中,模拟胃和肠液.
主要成果:
- 切削力粉碎阶段被确定为水凝微球尺寸的最佳控制阶段,从而产生了精确的尺寸控制模型.
- 单层和核心外水凝微囊在模拟的肠液中表现出明显更高的胀率,而不是模拟的胃液.
- 试验室释放研究表明,在模拟的胃汁中药物释放最小,在模拟的肠液中释放分化 (单层快速,核心缓慢).
结论:
- 基于酸盐的水凝微囊具有良好的稳定性和pH敏感性,使其适合在小肠中向药物输送.
- 微流体技术为定制药物释放提供了对水凝微囊大小和结构的精确控制.
- 开发的水凝微囊显示了有效和有针对性的药物输送的潜力,如Indometacin到小肠.
相关概念视频
01:24pH
The potential of hydrogen (pH) is a measure of the acidity or basicity of a water-based solution determined by the concentration of hydronium ions (H3O+). In one liter of pure water at neutral pH, there are 1×10−7 moles of hydronium ions. However, the extensive range of hydronium ion concentrations present in water-based solutions makes measuring pH in moles cumbersome. Therefore, a pH scale was developed to convert moles of hydronium ions into the negative logarithm of the hydronium ion...
01:24pH
The potential of hydrogen (pH) is a measure of the acidity or basicity of a water-based solution determined by the concentration of hydronium ions (H3O+). In one liter of pure water at neutral pH, there are 1×10−7 moles of hydronium ions. However, the extensive range of hydronium ion concentrations present in water-based solutions makes measuring pH in moles cumbersome. Therefore, a pH scale was developed to convert moles of hydronium ions into the negative logarithm of the hydronium ion...
01:21Stomach pH Regulation
The human body carefully regulates the internal pH of different organs to maintain homeostasis. For example, while the blood plasma maintains a neutral pH of 7, the stomach lumen has an acidic pH of 1.5 - 3.5. The low pH of stomach lumen helps kill pathogens in the food and break down complex food molecules.
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...
01:15Potentiometry: Membrane Electrodes
Membrane electrodes, also known as p-ion electrodes, use membranes that selectively interact with free analyte ions, generating a potential difference across the membrane. The resulting membrane potential, known as the asymmetry potential, is not zero even when analyte concentrations on both sides of the membrane are equal. The membrane's response is typically not selective to a single analyte but proportional to the concentration of all ions in the sample solution capable of interacting at the...
01:17Pore Transport and Ion-Pair Transport
Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct microscopic...
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct microscopic...
01:30Modified-Release Drug Delivery Systems: Stimuli-Activated
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...