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Updated: Jul 11, 2025

Proofreading and DNA Repair Assay Using Single Nucleotide Extension and MALDI-TOF Mass Spectrometry Analysis
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Proofreading and DNA Repair Assay Using Single Nucleotide Extension and MALDI-TOF Mass Spectrometry Analysis

Published on: June 19, 2018

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领先链DNA聚合酶epsilon的校对外核酶可以防止复制叉在破碎的模板链上崩

Tasnim Ahmad1, Ryotaro Kawasumi1, Tomoya Taniguchi1

  • 1Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Minamiosawa 1-1, Hachioji-shi, Tokyo 192-0397, Japan.

Nucleic acids research
|November 9, 2023
PubMed
概括

在单端双链断裂的DNA复制叉逆转是由PARP1,CTF18和Polε外核酶调解的. 这一途径,独立于同质导向修复,是olaparib的目标,增强其在癌细胞中的细胞毒性.

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Proofreading01:31

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