相关实验视频

Updated: Jul 11, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

在患有沙尔科毒症的患者中,循环中白素-23水平升高

Senol Kobak¹, Huseyin Semiz², Muhittin Akyildiz³

¹Istinye University Faculty of Medicine, Department of Internal Medicine and Rheumatology, WASOG Sarcoidosis Clinic, Turkey.

Reumatologia clinica

|November 9, 2023

概括

这项研究发现,在肉类发病患者中,血清中介质素-23 (IL-23) 含量升高,可能与脚关节炎有关. 其他测试的细胞因子 (IL-6,IL-12,IL-17) 与健康个体相比没有显著差异.

科学领域:

免疫学免疫学免疫学
类风湿病学类风湿病学
肺部病理学肺部病理学

背景情况:

沙丘病是一个慢性炎症性疾病,以颗粒瘤为特征,其确切的发病因子涉及正在调查中的促炎细胞因子.
类病中T助手1 (Th1) 介导途径和相关细胞因子在类病中的作用是研究的一个关键领域.

研究的目的:

在被诊断患有沙尔科毒症的患者中,检查血清中关键细胞因子水平,包括INTERLEUKIN-6 (IL-6),IL-12,IL-17和IL-23.
探索这些血清细胞因子水平与沙尔科毒症的临床和实验室表现之间的潜在相关性.

主要方法:

纳入了44名经过活检证明的型硬化症患者和41名健康志愿者的队列.
使用ELISA分析血清样本以量化IL-6,IL-12,IL-17和IL-23水平.
对所有参与者收集了全面的临床,实验室和放射学数据.

主要成果:

与对照组相比,在肉类发病患者中,血清IL-23水平明显高于对照组 (p=.01).
血清IL-23的升高与脚关节炎的存在有积极关联 (p=.02).
血清中IL-6,IL-12和IL-17的水平在肉病患者和对照人群之间没有显著差异.

结论:

这项研究发现,在肉类发病患者中,血清IL-23的增加表明了这种细胞因子的潜在作用.
虽然IL-6,IL-12和IL-17的水平被发现是正常的,但这些发现促使进一步调查沙丘病症作为Th1/Th17介导疾病.
建议进行多中心研究,以验证这些发现,并澄清细胞因子参与沙尔科毒性病原体的发生.

关键词:

血清性细胞因子增加了IL-23水平.增加IL-23的水平.Sarcoidosis 是一种癌症.血清中的细胞因子

更多相关视频

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

相关概念视频

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

The JAK-STAT Signaling Pathway

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...