脊椎动物和无脊椎动物中的甲状腺毒性以及生物活性化合物的改善:一篇综述
Anupam Kumar1, Shailja Jasrotia1, Joydeep Dutta2
1Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Punjab, India.
Pesticide biochemistry and physiology
|November 9, 2023
概括
类杀虫剂污染了生态系统,并损害了各种生命形式. 幸运的是,许多生物活性化合物可以在活体和实验室环境中减轻这些有害农药的影响.
科学领域:
- 环境毒理学环境毒理学
- 生物化学 生物化学
- 农业科学 农业科学
背景情况:
- 合成杀虫剂,特别是类杀虫剂,在农业中广泛使用,但会带来严重的环境和健康风险.
- 铁石污染了土壤和水,影响了各种陆地,水上和空中的生态系统.
- 尽管被认为是无毒的,但甲在脊椎动物和无脊椎动物系统中表现出严重的有害影响.
研究的目的:
- 为了研究常用的铁类药物对生物体的毒理影响.
- 识别和评估生物活性化合物的有效性,以抵消甲状腺激素诱导的毒性.
- 为减轻农药相关环境和健康问题的自然解决方案提供见解.
主要方法:
- 对甲状腺毒性和生物活性化合物的保护作用的科学文献的综述.
- 分析详细介绍甲状腺诱导损伤的机制的研究 (例如,氧化应激,器官毒性,DNA损伤).
- 收集有关各种天然化合物的数据,以及它们在体外和体内生物中降低农药毒性的已证明的能力.
主要成果:
- 甲类药物 (例如,Cypermethrin,Deltamethrin) 引起广泛的毒性作用,包括神经毒性,肝毒性,免疫毒性和DNA损伤.
- 许多生物活性化合物,如迪奥斯,库尔库,螺旋藻和绿茶提取物,在改善这些不良影响方面表现出有希望.
- 这些天然化合物通过各种机制有效地降低了甲状腺毒性,提供了潜在的缓解策略.
结论:
- 甲类杀虫剂由于它们的普遍毒性,对环境和动物健康构成重大威胁.
- 生物活性化合物提供了一种可行和自然的方法来抵消类杀虫剂的有害影响.
- 对这些天然化合物的进一步研究可能会导致更安全的农业实践和更好的环境保护.
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