下一代元基因组测序识别了一种罕见的Mycobacterium xenopi失联病例
Ali Zagham Nasir1, Nnaemeka Egwuatu2, Andrew Jameson2
1Internal Medicine Residency, Trinity Health Michigan, Grand Rapids, Michigan, USA ali.nasir@trinity-health.org.
BMJ case reports
|November 9, 2023
概括
基因组下一代测序 (MNGS) 快速检测出Mycobacterium xenopi骨感染,比传统培养早8周. 这一进步有助于在免疫功能低下患者中诊断罕见的机会性感染.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 基因组学就是基因组学.
背景情况:
- 包括Mycobacterium xenopi在内的非结核菌 (NTM) 可以引起机会性感染,特别是免疫功能低下个体的骨和关节感染.
- 传统的Mycobacterium xenopi培养方法是缓慢的,需要8-12周的生长时间,延迟了诊断和治疗.
- 甲基因组下一代测序 (MNGS) 提供了一种敏感和特定的基于血的检测微生物无细胞DNA.
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