患有全身性硬化症的患者衰竭的风险:一项基于全国人口的全国性研究
Oh Chan Kwon1, Kyungdo Han2, Min-Chan Park3
1Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea (the Republic of).
RMD open
|November 9, 2023
概括
与普通人群相比,患有全身性硬化症 (SSc) 的患者面临衰竭的风险明显更高. 这种高风险仍然存在,即使随着时间的推移,SSc相关的功能衰竭发病率下降.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 类风湿病学 类风湿病学
- 流行病学 流行病学
背景情况:
- 系统性硬化症 (SSc) 与衰竭的风险增加有关.
- 最近与SSc相关的功能衰竭发病率的趋势尚未完全理解.
- 随着时间的推移进行比较风险评估对于了解SSc对脏健康的影响至关重要.
研究的目的:
- 调查与普通人群相比,SSc患者衰竭的当代风险.
- 利用最近的全国数据,分析SSc患者中功能衰竭风险的趋势.
主要方法:
- 全国基于人口的研究,利用韩国国家医疗保险服务数据库.
- 包括2,591名SSc患者和12,955名匹配的对照 (2010-2017年).
- 多变量Cox比例危险模型用于估计功能衰竭的调整危险比率 (aHR).
主要成果:
- 患有SSc的患者患衰竭的风险增加了7.24倍 (aHR=7.244,95%CI=4.256至12.329).
- 在SSc患者中,发病率为每1000人年2.88%,对照组为0.35.
- 对于那些最近被诊断的人来说,风险明显更高 (2014-2017年,aHR=9.754).
结论:
- 与普通人群相比,系统性硬化症患者的衰竭风险仍然显著增加.
- 最近的诊断队列显示,功能衰竭风险的差异可能更大.
- 持续监测和主动性护对于SSc患者至关重要.
更多相关视频
08:505/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
23.7K
09:43Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
2.9K
相关概念视频
01:24Nephrotic Syndrome I : Introduction
8
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
8
01:24Chronic Kidney Disease II: Clinical Manifestations
11
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
11
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
18
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
18
01:24Nephrotic Syndrome III : Nursing Management
17
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
17
01:28Chronic Kidney Disease III: Interprofessional Care
13
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
13
01:22Acute Kidney Injury I: Introduction
12
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
12