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Updated: Jul 11, 2025

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trRosettaRNA:使用变压器网络自动预测RNA的3D结构

Wenkai Wang1, Chenjie Feng2,3, Renmin Han2

  • 1School of Mathematical Sciences, Nankai University, Tianjin, 300071, China.

Nature communications
|November 9, 2023
PubMed
概括

trRosettaRNA是一种用于RNA3D结构预测的新型深度学习方法. 它实现了高精度,在基准测试中与人类专家竞争,提供了一个有前途的自动化解决方案.

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RNA Structure

The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
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One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
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Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
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