在小鼠的认知衰老背后的前额回路的功能性改变
Huee Ru Chong1, Yadollah Ranjbar-Slamloo1, Malcolm Zheng Hao Ho1,2
1Neuroscience & Mental Health, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 308232, Singapore.
Nature communications
|November 9, 2023
概括
认知衰老通过改变中部前额叶皮层 (mPFC) 中的神经回路来损害执行功能. 中年期显示跨模式记忆编码和电路连接性减弱,随着年龄的增长而恶化.
科学领域:
- 神经科学是一个神经科学.
- 认知衰老研究 认知衰老研究
- 计算神经科学是一种神经科学.
背景情况:
- 执行功能随着年龄的增长而下降,但根本的电路级变化尚未完全理解.
- 中间前额叶皮质 (mPFC) 对于执行功能,包括工作记忆至关重要.
研究的目的:
- 调查老化如何影响记忆引导行为期间mPFC中神经计算和电路连接.
- 识别工作记忆处理中早期出现的与年龄相关的变化.
主要方法:
- 在执行记忆指导任务的小鼠中进行成像和光遗传学操纵.
- 在mPFC中对人口活动和静止状态功能连接的分析.
- 使用光遗传性失活来评估电路漏洞.
主要成果:
- 工作记忆的编码和mPFC中的反复连接在中年时会发生变化.
- 交叉模态记忆编码在中年减少,而模态依赖编码持续存在,但在晚年衰退.
- 休息状态的功能连接性在中年降低,这表明循环循环的恶化.
结论:
- 中年标志着与认知衰老相关的前额叶皮质电路功能变化的开始.
- 衰退的循环循环和mPFC中神经编码的改变有助于与年龄相关的执行功能下降.
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