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尼格罗斯特里亚特多巴胺调节了在听觉恐惧调节中的条状桃体通路
Allen P F Chen1,2, Lu Chen1, Kaiyo W Shi1
1Department of Neurobiology and Behavior, SUNY Stony Brook, Stony Brook, NY, 11794, USA.
Nature communications
|November 9, 2023
概括
听觉条纹体对于听觉恐惧记忆至关重要. 抑制这些神经元会损害记忆,突出显示黑色-状-杏仁体电路.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 记忆研究 记忆研究
背景情况:
- 听觉条纹体是背状条纹体的一部分,对学习和记忆至关重要.
- 它在古典的听觉恐惧调节中的作用尚不清楚,与其在操作调节中的已知功能不同.
研究的目的:
- 阐明听觉条纹体在听觉条件下的恐惧记忆中的功能.
- 调查听觉恐惧记忆的形成和表达背后的神经通路和机制.
主要方法:
- 在小鼠中对听觉条状神经元的光遗传抑制.
- 在行为小鼠中进行成像,以监测神经元活动.
- 调查条状腺-桃体通路和阴条状腺多巴胺基质投射.
主要成果:
- 抑制听觉条状神经元显著损害了听觉恐惧记忆的形成.
- 听觉条状神经元对条件调的反应,在记忆获取和表达过程中被强化.
- 听力条状体中调节的条件诱导的强化是黑状体的多巴胺基突出的投射.
结论:
- 听觉条纹体对于听觉条件下的恐惧记忆至关重要.
- 一个黑色-状-桃体电路介导了条件恐惧记忆的形成和表达.
- 多巴胺基通路在调节这种恐惧记忆电路方面发挥着关键作用.
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