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Updated: Jul 11, 2025

Ultrastructural Localization of Endogenous LC3 by On-Section Correlative Light-Electron Microscopy
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Ultrastructural Localization of Endogenous LC3 by On-Section Correlative Light-Electron Microscopy

Published on: March 31, 2023

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激活NLRP3的ASC复合体的冷电子断层扫描显示了有机体的同定位

Yangci Liu1,2, Haoming Zhai1,2, Helen Alemayehu1,2

  • 1Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.

Nature communications
|November 9, 2023
PubMed
概括

激活NLRP3会触发炎症酶组合,从而导致热亡. 这项研究可视化了ASC细丝及其与有机细胞的相互作用,揭示了疾病中细胞死亡的机制.

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Do's and Don'ts of Cryo-electron Microscopy: A Primer on Sample Preparation and High Quality Data Collection for Macromolecular 3D Reconstruction

Published on: January 9, 2015

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The CryoAPEX Method for Electron Microscopy Analysis of Membrane Protein Localization Within Ultrastructurally-Preserved Cells11:45

The CryoAPEX Method for Electron Microscopy Analysis of Membrane Protein Localization Within Ultrastructurally-Preserved Cells

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相关概念视频

Cryo-electron Microscopy01:28

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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