在2型糖尿病患者中,周周细胞微血管结构的变化:全身高血压的影响
Jae-Yun Sung1, Kook-Hyung Lee2, Ji-Ho Jun2
1Department of Ophthalmology, Chungnam National University Sejong Hospital, Sejong, Republic of Korea.
Scientific reports
|November 9, 2023
概括
在没有糖尿病视网膜病变的2型糖尿病患者中,高血压会恶化周周细胞微血管. 这种情况,结合高血压,导致更严重的微血管恶化和潜在的视网膜神经纤维层稀薄.
科学领域:
- 眼科医生 眼科 眼科
- 心血管研究研究心血管研究
- 糖尿病学 糖尿病学
背景情况:
- 2型糖尿病 (T2DM) 是微血管并发症的主要原因.
- 糖尿病视网膜病变 (DR) 是一种已知的影响视网膜微血管的并发症.
- 高血压 (HTN) 对没有DR的T2DM患者周周血管微血管的特定影响需要进一步阐明.
研究的目的:
- 为了研究高血压对2型糖尿病患者在没有糖尿病视网膜病变的周周细胞微血管系统的影响.
- 为了比较对照,T2DM和T2DM与HTN组之间的周周血管密度 (VD).
- 在这个患者队列中确定与周围皮囊静脉疾病相关的因素.
主要方法:
- 追溯分析了来自三个组的286只眼睛:对照组 (124),T2DM (111),以及带HTN的T2DM (51).
- 周周血管密度 (VD) 被测量并使用协变分析进行比较,调整为年龄和最佳校正视力敏度.
- 线性回归分析被用来确定影响周周毛囊性静脉疾病的因素.
主要成果:
- 与对照组相比,T2DM患者的周周血管疾病显著较低 (P < 0.001).
- 与并发性HTN患者的T2DM患者表现出明显较低的周包膜静脉疾病比对照组和仅T2DM组 (P < 0.001).
- 高血压 (P = 0.043) 和周周细胞状视网膜神经纤维层 (pRNFL) 厚度 (P < 0.001) 与T2DM患者周周细胞状静脉疾病的减少显著相关.
结论:
- 在T2DM患者中,即使没有临床DR,周周细胞微血管也受损.
- 并发性高血压加剧了T2DM患者周周细胞微血管系统的恶化.
- 高血糖和高血压的综合作用导致更严重的微血管损伤,可能反映在pRNFL稀释中.
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