使用尿液FTIR光谱来查自闭症谱系障碍
Neslihan Sarigul1, Leyla Bozatli2, Ilhan Kurultak3
1Institute of Nuclear Science, Hacettepe University, Ankara, Turkey. nsarigul@hacettepe.edu.tr.
Scientific reports
|November 9, 2023
概括
减弱总反射率-里埃变换红外光谱 (ATR-FTIR) 显示了自闭症谱系障碍 (ASD) 查的潜力. 尿液FTIR光谱显示了ASD儿童的明显差异,提供了一个非侵入性的诊断方法.
科学领域:
- 生物化学 生物化学
- 频谱学是一种光谱学.
- 神经发育障碍 神经发育障碍
背景情况:
- 自闭症谱系障碍 (ASD) 诊断依赖于行为症状,需要长时间观察,缺乏明确的生物标志物.
- 目前对ASD的诊断方法对临床医生和家长都很苛刻,没有普遍接受的实用工具.
- 自闭症的异质性需要新的,客观的诊断方法.
研究的目的:
- 调查减弱总反射率-里埃变换红外光谱 (ATR-FTIR) 对自闭症谱系障碍 (ASD) 的诊断潜力.
- 为了确定ASD儿童和典型发育 (TD) 儿童之间的尿样中的光谱差异.
- 探索ATR-FTIR作为一种实用的,非侵入性的ASD查工具.
主要方法:
- 研究了26名患有自闭症儿童 (年龄为3-5岁) 和26名年龄/性别匹配的对照.
- 使用减弱总反射率-里埃变换红外光谱 (ATR-FTIR) 来分析尿样.
- 应用主要成分分析 (PCA) 来识别光谱特征,并使用人工尿溶液将它们与尿液成分相关联.
主要成果:
- 尿液FTIR光谱显示,与TD儿童相比,ASD儿童的3000-2600/cm区域下降趋势.
- 该地区的平均面积在不同严重程度的ASD+儿童中显著减少 (16-29%).
- PCA确定了五个关键峰值,其中尿酸,酸和的较低水平被认为是潜在的原因.
结论:
- ATR-FTIR光谱显示出作为查ASD的实用和非侵入性方法的潜力.
- 对尿液FTIR光谱高频区域的分析可以区分患有自闭症和没有自闭症的儿童.
- 这种光谱方法可能有助于开发用于ASD诊断的客观生物标志物.
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