中年后期非洲裔美国人的低循环阿德罗宾水平,认知表现不佳
Geetika Aggarwal1,2,3, Theodore K Malmstrom2,4, John E Morley1
1Division of Geriatric Medicine, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, MO, USA.
npj aging
|November 9, 2023
概括
低水平的氨基与中年非洲裔美国人的认知功能较差有关. 这表明阿德罗可能是认知障碍和认知能力下降的早期指标.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 老年学是一门学科.
背景情况:
- 阿德罗是一种在人类神经系统中高度表达的分泌.
- 以前的研究将低氨酸与老年欧洲人的认知能力下降联系在一起.
- 大脑中的阿德罗表达与痴呆症风险途径相关,并改善老年小鼠的认知能力.
研究的目的:
- 调查循环阿德罗宾度与中后期的非洲裔美国人的认知功能之间的关联.
- 探索不同类型的大脑细胞中的阿德罗宾表达及其与衰老和炎症的关系.
主要方法:
- 352名非裔美国人 (45-65岁) 的认知得分和阿德罗宾水平的二项逻辑回归分析.
- 从人类中旋 (MTG) 分析单核RNA测序数据,以评估跨细胞类型的腺素表达.
- 在体外研究培养的人类星体细胞,以检查阿德罗宾表达的变化与年龄和炎症因素.
主要成果:
- 低循环阿德罗宾度与非洲裔美国人的认知功能不佳显著相关 (OR=0.775,P<0.05).
- 在人体MTG内的星细胞中,阿德罗的表达最高,并且随着捐赠者的年龄而下降.
- 氨酸的表达与能量代谢和蛋白质合成特征有积极的相关性,并受到促炎因素的抑制.
结论:
- 低循环阿德罗水平可能作为认知障碍的早期风险指标.
- 受神经炎症影响的老化大脑细胞中阿德罗宾表达的下降是将老化与认知衰退联系在一起的潜在机制.
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