间歇性与持续性养对重症患者的代谢影响
D Wilkinson1,2,3, I J Gallagher4, A McNelly5
1MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, Metabolic and Molecular Physiology, University of Nottingham, Queen's Medical Cetnre, Nottingham, UK.
Scientific reports
|November 9, 2023
概括
与连续养相比,重症患者间歇性肠道养没有改变代谢模式. 这项研究发现,在10天的时间里,氨基酸,脂肪或碳水化合物代谢物没有显著变化.
科学领域:
- 关键护理医学 关键护理医学
- 营养科学 营养科学
- 代谢学 代谢学 代谢学
背景情况:
- 间歇性肠道养对危急病患者的营养输送之外的潜在益处越来越感兴趣.
- 潜在的益处包括昼夜节律的调节,睡眠,林分泌,胰岛素抵抗和自.
- 描述代谢变化对于理解不同食方案的影响至关重要.
研究的目的:
- 在接受间歇性与连续性肠道养的重症患者中,对氨基酸,脂肪和碳水化合物代谢物度的变化进行表征.
- 为了研究食方案对代谢物模式的影响,随着时间的推移 (10天) 和24小时内.
主要方法:
- 一个八个中心,单盲,随机对照试验 (NCT02358512) 涉及75名重症患者.
- 患者被随机分配,接受连续或间歇性 (6x/day) 肠道养.
- 使用核共振光谱对594个血液样本进行了有针对性的代谢分析.
主要成果:
- 在一天内或10天的采样中,没有广泛的代谢物模式区分间歇性和连续养臂.
- 观察到与氨基酸,体,脂肪酸和碳水化合物代谢相关的代谢物减少.
- 代谢物变化与四头肌肌肉质量之间没有发现相关性.
- 器官衰竭的严重程度增加与体代谢,卡尼丁缺乏和氨酸水平相关.
结论:
- 每天6次间歇性肠道食方案与危急病患者的连续食相比,没有改变代谢物模式.
- 研究结果表明,间歇性养在24小时内或10天内不会对代谢概况产生广泛的影响.
- 未来的研究应该探索临床过程的益处或与间歇性食方案相关的延长肠道休息.
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