对于晚期泌尿癌的全身疗法的进展
Rosa Nadal1, Begoña P Valderrama2, Joaquim Bellmunt3,4
1National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Nature reviews. Clinical oncology
|November 9, 2023
概括
晚期泌尿腺癌 (aUC) 治疗已经发展成为新的疗法,如免疫检查点抑制剂和抗体-药物联合体. 然而,生物标志物开发和对这种无法治愈的癌症的治疗顺序仍然存在挑战.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 尿癌研究 尿癌研究
背景情况:
- 晚期泌尿腺癌 (aUC) 的预后不好,五年生存率约为10%.
- 基于的化疗是大多数aUC患者的标准第一线治疗.
- 最近的批准引入了新的治疗选择,改善了生存结果.
研究的目的:
- 审查晚期泌尿腺癌全身疗法的发展情况.
- 突出最近的治疗进展及其对患者结果的影响.
- 确定未满足的需求和aUC治疗的未来方向.
主要方法:
- 目前关于晚期泌尿腺癌全身疗法的文献综述.
- 分析最近的临床试验结果和药物批准.
- 讨论新兴的治疗方式和正在进行的研究问题.
主要成果:
- 艾维卢马布 (抗PD-L1) 维持疗法改善了那些在化疗中没有初步进展的患者的生存率.
- 第一线免疫检查点抑制剂 (ICI) 主要用于不合格的患者.
- 新的药物如恩福图马布维多丁,布罗利祖马布和萨基图祖马布戈维特可在各种治疗环境中显示出前景.
结论:
- 在先进的泌尿腺癌系统治疗方面取得了重大进展.
- 关键的挑战包括需要预测生物标志物和优化治疗序列.
- 未来的研究方向包括抗体-药物合物,下一代ICI,双特异性抗体和细胞疗法.
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