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Updated: Jul 11, 2025

Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells
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Published on: April 4, 2016

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圆形外染色体DNA促进高风险脑髓母细胞瘤的瘤异质性

Owen S Chapman1,2,3, Jens Luebeck1,4, Sunita Sridhar2,5

  • 1Bioinformatics and Systems Biology Graduate Program, University of California San Diego, San Diego, CA, USA.

Nature genetics
|November 9, 2023
PubMed
概括

循环外染色体DNA (ecDNA) 通过改变基因表达和抵抗来驱动癌症. 在脑髓母细胞瘤中检测到ecDNA显示,它显著增加了患者的复发和死亡风险.

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