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乳房的生理吸收特征在68 Ga-FAPI-04 PET/CT上

Yue Zhang¹, Yushan Zhou¹, Rong Tian¹

¹Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, Sichuan, China.

Molecular imaging and biology

|November 9, 2023

概括

在正常乳腺组织中高生理68 (Ga) 标记的纤维细胞激活蛋白抑制剂 (FAPI) 的吸收可能会影响乳腺癌的分期. 月经状态显著影响Ga-FAPI-04在正常乳腺组织中的吸收,在高雌激素阶段的吸收更高.

科学领域:

核医学是一种核医学.
在瘤学瘤学.
放射化学放射化学是指辐射化学.

背景情况:

标记Ga的纤维细胞激活蛋白抑制剂 (FAPI) PET/CT显示出对乳腺癌分期的承诺.
在正常乳腺组织中高生理吸收Ga-FAPI-04可能会掩盖原发性瘤.
了解生理吸收模式对于在乳腺成像中准确解释FAPI PET/CT至关重要.

研究的目的:

描述Ga-FAPI-04在正常乳腺组织中的生理吸收.
确定影响乳房和乳头Ga-FAPI-04吸收的因素.
通过了解背景吸收来评估Ga-FAPI-04 PET/CT对乳腺癌分期的临床实用性.

主要方法:

对143名拥有68个Ga-FAPI-04 PET/CT数据的女性进行了回顾性审查.
测量SUV_max,乳腺密度,乳腺厚度和乳头的SUV_max.
单变量和多变量回归分析以确定与乳房和乳头SUV相关的因素.

主要成果:

双边乳房之间的Ga-FAPI-04吸收没有显著差异.
月经状况是乳腺SUV的重要独立预测因素,在高雌激素阶段 (晚期卵泡,排卵,中期乳房) 吸收更高.
乳SUV与月经状况没有相关性.

结论:

在正常乳腺组织中Ga-FAPI-04的生理吸收受月经状态和雌激素水平的影响.
月经状况是解释乳腺癌的Ga-FAPI-04 PET/CT时要考虑的关键因素.
需要进行进一步的研究,以优化Ga-FAPI-04 PET/CT用于乳腺癌分期的使用,考虑到生理变异.

关键词:

68Ga-FAPI-04 聚乙酸/聚乙烯/聚乙烯乳房乳房乳房月经状态月经状态生理学生理学生理学

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