动脉瘤下arachnoid出血中的危险因素协同作用:一个横截面研究
Jack Henry1, Michael Amoo2,3, Mohamed O Dablouk2
1National Neurosurgical Centre, Beaumont Hospital, Dublin, 9 D09 V2N0, Ireland. jackmhry@pm.me.
Acta neurochirurgica
|November 9, 2023
概括
自发性下关节出血 (SAH) 与吸烟密切相关,这是主要的危险因素. 联合吸烟和高血压显著放大了SAH风险,表明了协同效应.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 自发性下关节出血 (SAH) 占中风病例的很大一部分,导致大量的发病率.
- 确定的SAH风险因素包括吸烟,高血压,晚年和女性性别.
研究的目的:
- 在代表性人群中确定动脉瘤下arachnoid出血 (aSAH) 的发生率.
- 确定和量化关键风险因素的关联,包括吸烟和高血压,与aSAH发病率.
主要方法:
- 一个横截面的研究设计,利用2017-2020年全国代表性患者队列.
- 动脉瘤性SAH病例通过前性数据库和死亡记录来确定.
- 普森回归模型用于计算已识别的风险因素的发病率和发病率比率 (IRR).
主要成果:
- 这项研究发现了875例aSAH病例,标准化发病率为每10万人/年6.1.
- 吸烟成为最强的个人风险因素 (年龄调整后的IRR为9.2),高血压吸烟者的发病率最高 (63/100,000),35岁以后的终身风险为6.7%.
- 高血压 (年龄调整后的IRR为3.1) 和女性性别 (年龄调整后的IRR为1.8) 也与aSAH发病率的增加显著相关.
结论:
- 吸烟被确定为aSAH最重要的个人风险因素.
- 吸烟和高血压之间的协同相互作用大大提高了aSAH的风险.
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