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Updated: Jul 11, 2025

Untargeted Metabolomics from Biological Sources Using Ultraperformance Liquid Chromatography-High Resolution Mass Spectrometry UPLC-HRMS
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使用基于HRMS的策略,对人类尿液中的外源化学物质进行全面的分析和半量化

Daniel Gutiérrez-Martín1,2,3, Esteban Restrepo-Montes1, Oksana Golovko4

  • 1Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research - Severo Ochoa Excellence Center (IDAEA), Spanish Council of Scientific Research (CSIC), 08034, Barcelona, Spain.

Analytical and bioanalytical chemistry
|November 9, 2023
PubMed
概括

这项研究验证了一种用于人类生物监测的新方法,使用高分辨率质谱仪精确分析尿液中的2000多种化学物质. 该高效的协议绕过了耗时的解步骤,以进行更广泛的化学暴露评估.

关键词:
解合解合是一种解合.葡萄糖化物 葡萄糖化物高分辨率质谱仪 (HRMS) 是一种高分辨率的质谱仪.人类生物监测 (HBM)方法验证方法的验证方法.没有目标的非目标

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The resolution of a mass spectrometer depends on the efficiency of separating ions with different ion masses. The mass of an atom is approximated to the sum of the masses of protons and neutrons inside, considering the masses of protons and neutrons as equal. However, the masses of the proton (1.6726 × 10−24 g) and neutron (1.6749 × 10−24 g) are not truly equal. There is a minor error in the expression of atomic masses relative to the simplest atom of hydrogen. For...
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