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Updated: Jul 11, 2025

Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA

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Published on: July 9, 2021

使用基于多个网络的深度神经网络预测 lncRNA 功能

Lei Deng¹, Shengli Ren¹, Jingpu Zhang²

¹School of Computer Science and Engineering, Central South University, 410075, Changsha, China.

|November 10, 2023

概括

一种新的计算方法,DNGRGO,使用全球异质网络预测长非编码RNA (lncRNA) 功能. 这种方法改进了现有的方法,通过利用蛋白质和miRNA的相似性来准确的lncRNA注释.

科学领域:

基因组学就是基因组学.
生物信息学是一种生物信息学.
计算生物学计算生物学

背景情况:

长非编码RNAs (lncRNAs) 在生物体生理学中起着至关重要的作用,但它们的功能仍然在很大程度上没有特征.
生物数据库中 lncRNA 数据的指数增长需要用于功能注释的先进计算方法.
了解 lncRNA 功能对于推动生物研究和治疗开发至关重要.

研究的目的:

开发一种新的计算方法,用于预测长非编码RNA (lncRNAs) 的功能.
为了有效地利用生物数据库中 lncRNA相关数据的数量不断增加.
为了提高 lncRNA 功能注释的准确性和效率.

主要方法:

提出DNGRGO,一种基于全球异质网络的计算方法,用于lncRNA功能预测.
计算了蛋白质,miRNA和lncRNA之间的相似性.
标注的lncRNA通过识别具有已知的基因本体学 (GO) 标注的类似蛋白质编码基因来发挥作用.

主要成果:

与现有方法相比,DNGRGO表现出优越的预测性能,实现了最大的F测量和覆盖范围.
手动注释GO术语到lncRNAs验证了该方法的有效性.
集成miRNA数据显著提高了DNGRGO的预测准确性.

结论:

DNGRGO通过捕捉异构网络中的低维特征来有效地注释lncRNAs.
该方法为探索未表征的lncRNAs的功能提供了有价值的工具.
整合miRNA数据是改进lncRNA功能预测模型的一个有希望的策略.

关键词:

基因本体学是基因的本体学.网络代表性网络代表性这就是为什么PPMI是PPMI.这是SDAEE.在ncRNA功能中,

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相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

Types of RNA

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

Protein Networks

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...