黑色素瘤和CLL的同时发生和生存率:KC史的作用
Yayi Zhao1, Rossybelle P Amorrortu1, Sandra C Stewart2
1Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
BMC cancer
|November 10, 2023
概括
患有非黑色素瘤性皮肤癌史预测黑色素瘤的生存率,但不预测慢性淋巴细胞白血病 (CLL) 的生存率. 早期的血液标志物可能有助于识别患有无症状CLL风险的患者.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 血液学 血液学 血液学
背景情况:
- 以前的非黑色素瘤皮肤癌 (角质细胞癌 (KC)) 病史与黑色素瘤和慢性淋巴细胞白血病 (CLL) 的存活率有关.
- 黑色素瘤和CLL可以同时发生,但它们的联合存活率和KC病史的作用尚未得到充分研究.
研究的目的:
- 研究KC病史与黑色素瘤和/或CLL患者的存活率之间的关联.
- 探索黑色素瘤,CLL和KC的同时发生,以及它们对患者结果的影响.
主要方法:
- 对被诊断患有黑色素瘤和/或CLL的患者进行了回顾性队列研究 (2008-2020年).
- 多变量考克斯回归分析了KC史与生存的关联.
- 嵌套病例对照研究比较了黑色素瘤,CLL或两种病症患者的血液参数.
主要成果:
- 肯尼基癌史与4年内有利的黑色素瘤存活率相关,但7年后的存活率较差.
- 肯尼基癌史对CLL存活率没有显著影响,即使是同时发生黑色素瘤.
- 同时发生的黑色素瘤和CLL患者通常首先患有黑色素瘤,白细胞和淋巴细胞数量增加.
结论:
- 凯氏细胞史独立预测黑色素瘤存活率,而不是CLL存活率.
- 黑色素瘤诊断时的血液参数可以识别具有无症状CLL高风险的个体,有助于早期诊断.
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