相关实验视频

Updated: Jul 11, 2025

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

针对多发性硬化症的基于免疫检查点的免疫疗法的进展:理由和实践

Amin Daei Sorkhabi¹, Erfan Komijani², Aila Sarkesh¹

¹Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

Cell communication and signaling : CCS

|November 10, 2023

概括

免疫检查点抑制剂通过恢复免疫平衡来治疗多发性硬化症 (MS) 是有前途的. 战略重点是调节抑制和刺激检查点,以对抗MS相关的神经退行.

科学领域:

免疫学免疫学免疫学
神经免疫学神经免疫学
在瘤免疫学上.

背景情况:

免疫检查点抑制剂 (ICP) 在癌症治疗中有效.
失调的ICP与多发性硬化症 (MS) 和实验性自身免疫脑膜炎 (EAE) 有关.
ICPs调节免疫耐受性和平衡刺激/抑制路径.

研究的目的:

审查针对自身免疫性疾病的基于ICP的免疫疗法,特别是MS.
探索在MS治疗中调节ICP的策略.
讨论ICP在管理MS相关的自身免疫和神经退行症方面的潜力.

主要方法:

关于癌症和自身免疫性疾病中ICP的当前文献的综述.
在MS和EAE模型中分析ICP表达模式.
讨论涉及ICP调制的治疗策略.

主要成果:

ICP在维持免疫平衡中发挥着至关重要的作用.
改变ICP表达与MS病原和神经退行有关.
目前正在为MS治疗制定各种基于ICP的策略.

结论:

基于ICP的免疫疗法为MS治疗提供了一个有希望的途径.
准ICPs可以帮助恢复免疫耐受性并减少神经炎症.
对ICP调制的进一步研究有可能为有效的MS治疗策略提供潜力.

关键词:

欧洲电子商务管理局 (EEAE)实验性自身免疫性脑炎免疫检查站检查站免疫治疗是一种免疫疗法.多发性硬化症是多发性硬化症.

更多相关视频

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.